Surfactant replacement therapy--time for thought.

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[Surfactant replacement therapy]

OBJECTIVE: To analyze and update information about surfactant therapy replacement in newborns with lung diseases. SOURCES: Literature review, including textbooks, meta-analyses, prospective, randomized controlled trials, retrospective assessments and case studies. Literature was reviewed based on the authors clinical and scientific experience regarding surfactant replacement therapy in neonatal...

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Three-dimensional model of surfactant replacement therapy.

Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respiratory distress syndrome (ARDS), early successes were followed by failures. This un...

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Surfactant Replacement Therapy: Benefits and Risks

Surfactant deficiency at birth makes it difficult for the newborn to inflate its lungs. As the infant makes increasingly vigorous attempts to ventilate noncompliant lungs, delayed adsorption of lung fluid, pulmonary edema, extravasation of plasma proteins into air spaces, and lung injury occur, which cause progressive respiratory distress. Intratracheal administration of surfactant into the inf...

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New targets for surfactant replacement therapy: experimental and clinical aspects.

The benefits of surfactant replacement therapy for neona-tal respiratory distress syndrome (RDS) have been well documented in several randomised trials, and this treatment is now part of routine clinical management of babies with immature lungs. Meta-analysis of data from a large number of babies treated in controlled trials has confirmed lower mortality and reduced incidence of complications ,...

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Surfactant Replacement Therapy Beyond Respiratory Distress Syndrome in Neonates.

BACKGROUND Surfactant replacement therapy is an established modality of treatment in preterm neonates with respiratory distress syndrome. In addition, there are various neonatal respiratory disorders which are characterized by surfactant deficiency in which surfactant therapy can be a feasible and safe option. OBJECTIVE To collate the literature on the use of surfactant replacement therapy in...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1992

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.67.10_spec_no.1228